Resistance Rates to Various Antimicrobial Agents of Helicobacter pylori Isolates in Eastern Turkey

Document Type : Research Article


1 Vocational School of Health Services, Firat University, 23119, Elazig, Turkey

2 Department of Gastroenterology, Faculty of Medicine, Firat University, 23119, Elazig, Turkey

3 Vocational School of Health Services, Bingol University, 12000, Bingol, Turkey


The aim of this study was to determine the resistance rates of Helicobacter pylori (H. pylori) to various antimicrobial agents. The agar disk diffusion method (Kirby Bauer) was used to determine the sensitivity of H. pylori isolates to various antimicrobials. Of the 61 H. pylori isolatestested, no isolates was resistant to amoxycillin and tetracycline. The resistance rates were 42.6% for metronidazole, 21.3% for clarithromycin, and 3.3% for levofloxacin. Compared to clarithromycin and metronidazole, levofloxacin showed the lowest resistance. This is the first report on the resistance rates of H. pylori to antibiotics in Elazig Province, East of Turkey. This study suggests that the large scale studies is needed to help us to understand better the effect of resistance on the H. pylori eradication.