Determination of antibiotic susceptibility and Minimum Inhibitory Concentration (MIC) of the Propionibacterium acnes to the prevalent antibiotics in the treatment of Acne vulgaris

Document Type : Research Article


1 Department of Microbiology, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran.

2 Department of Microbiology,Tonekabon Branch, Islamic Azad University, Tonekabon, Iran.



Propionibacterium acnes is propounded as one of the significant factors in occurrence of acne. Today, due to development of the antibiotic resistance, most of the acne treatments are faced with failure. In order to determine the antibiotic resistance of the P.acnes strains isolated from the patients with acne, this research has been carried out. 70 samples collected using microbial culture technique were studied in order to identify P.acnes. Antibiotic resistance of the strains isolated by antibiogram method to the antibiotics, including Erythromycin, Clindamycin and Tetracycline being the preferred antibiotics in the acne treatment was determined. Of total 70 studied samples, 14 positive samples (20%) were identified in terms of presence of the P.acnes. Rate of antibiotic resistance to Erythromycin, Clindamycin and Tetracycline was determined to be 50%, 35.71% and 14.29% respectively. Outbreak of antibiotic resistance of the P.acnes to Erythromycin and Clindamycin is in high level. Since P.acnes is sensitive to Tetracycline in a noticeable amount, it is recommended this antibiotic is to be used to treat acne.


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