Determination of antibiotic sensitivity by E-test in resistant Enterococcus species isolated from patients admitted in Khatam- Ol – Anbiya Hospital, Tehran, Iran, , 2013-2015

Document Type : Research Article


1 Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran

2 School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran


Enterococcus is the second cause of urinary tract infections in hospitals and the third most common cause of nosocomial bacteremia. Overuse of antibiotics for the treatment of nosocomial infections, causes antibiotic resistance in enterococci resistant to antibiotics through their ability to acquire resistance to antibiotics through mutation or acquisition of genetic material carrying a resistance gene by conjugation or other methods.

This cross-sectional study, studied all of the patients admitted in the Khatam – Ol- Anbiya hospital wards during 2013-2015 that 60 cases of patients with nosocomial infections during this period . Demographic data collected from medical records. Samples collected and were sent to the microbiology laboratory. In order to investigate drug-resistant Enterococcusو Antibiogram test by E-Test method were performed. Relevant descriptive variables were analyzed in SPSS software version 21 .

34 (56/7%) of patients were male. The patient age mean was 70/71+ 18/39 years. Age group 70-90 years, with 17 (27.9 %) were the most frequent nosocomial infections. Enterococcus dominant species in these patients was 45 (75%) Enterococcus faecalis. Antibiogram E-Test results showed that 9 cases (18.3%) were resistance to linezolid, 22 (36/7 %) resistance to imipenem, 15 (25 %) resistance to meropenem, 6 patients (10% ) resistance to teicoplanin, 9 (15%) were resistant to vancomycin.

Identification of common antibiotic resistance in every region has great importance and in addition prevents treatment failure. The result of these studies shows that, antibiotic-resistance patterns have changed, and vancomycin resistance, especially among E. faecium, is rising because of nosocomial infections


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