Prevalence of Helicobacter pylori in patients with colorectal cancer

Document Type: Research Article

Authors

1 Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2 Department of Microbiology,School of Medicine,Shahid Beheshti University of Medical Sciences,Tehran,Iran

3 Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran

4 Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

5 School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Abstract

Colorectal cancer (CRC) has defined as the uncontrolled growth of cells in the colon or rectum. The human colon contains the greatest number of microbes Therefore, microbes may play an important role in the development of colorectal cancer. Recent studies have shown an association between the microbial infection and the risk of colorectal cancer. However, the results of these studies are controversial. The nobility of the present study was to assess the prevalence of Helicobacter pylori infection in the colorectal cancer in Iran. The biopsy were done and the samples were obtained from patients suspected with colorectal cancer, from 2015 to 2017.Secondary, DNA of Helicobacter pylori was extracted by Commercial kit. PCR was performed for Helicobacter pylori glmM gene eventually, the data was analysed. A total of 86 patients in which 68 of them confirmed with CRC and 17 patients considered as controls. Of 68 biopsy specimens and control group, all of them were negative for Helicobacter pylori. It was ultimately attained that in colorectal cancer, there was no presence of Helicobacter pylori.

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