Isolation of Halophilic Bacteria from Maharlu salt Lake - Iran and their evaluation for the production of bioactive compounds

Document Type : Research Article


1 Department of Microbiology, Kazeroon Branch, Islamic Azad University of Kazeroon, Kazeroon, Iran

2 Department of Microbiology, Shiraz Branch, Islamic Azad University of Shiraz, Shiraz, Iran


Halophilic bacteria grow over a wide range of salt concentrations. In this study we aimed to isolate and screen out the halophilic bacteria and to determine their activity for production of the bioactive compounds. A total of 50 water, sediments and soil samples were collected from Maharlu salt lake in southern region of Fars-Iran and subjected for isolation of the bioactive compound producing Halophilic bacteria. The results obtained indicated that out of all isolates, three strains could produce the bioactive compounds. The isolates were molecular (16SrRNA) identified as Bacillus licheniformis, Bacillus subtilis and Bacterium Culaeen. Furthermore, structural analysis of the bioactive compounds was carried out in order to achieve maximum information concerning to them. The results obtained illustrated the existence of glycoprotein in all the bioactive compounds. Although, Staphylococcus aureus, Aspergillusniger and Mucor…. were sensitive to all the bioactive compounds, Pseudomonas aeruginosa, Escherichia coli and Bacillus cereus were resistant to them. In addition, the bioactive compound producing isolated strains by Bacillus licheniformis and Bacillus subtilis showed antifungal activity against Aspergillusniger and mucor sp. In total, our finding illustrated that the maharlu salt lake might be considered a source of halophilic bacteria with potent activity for production of the bioactive compounds. In addition, isolation and characterization of these compounds culminate in the achievement of the new drugs.